Infective Endocarditis After Transcatheter Versus Surgical Aortic Valve Replacement

Authors: Vassili Panagides, Guillermo Cuervo, Jaume Llopis, Mohamed Abdel‐Wahab, Norman Mangner, Gilbert Habib, Ander Regueiro, Carlos A. Mestres, Pilar Tornos, Éric Durand, Christine Selton‐Suty, Nikolaj Ihlemann, Niels Eske Bruun, Marina Ureña, Enrico Cecchi, Hölger Thiele, Emanuele Durante‐Mangoni, Costanza Pellegrini, Hélène Eltchaninoff, Eugene Athan, Lars Søndergaard, Axel Linke, Pierre Tattevin, David del Val, Eduard Quintana, Vivian H. Chu, Josep Rodés‐Cabau, José M. Miró, TAVI Infective Endocarditis International Registry and ICE Investigators, Liliana Clara, Marisa Sánchez, José Casabé, Claudia Cortés, Francisco Nacinovich, P. Fernandez Oses, Ricardo Ronderos, Adriana Sucari, Jorge Thierer, Javier Altclas, Silvia Kogan, Denis Spelman, Eugene Athan, Owen Harris, Karina Kennedy, Ren Tan, David Gordon, Lito E. Papanicolas, Tony M. Korman, Despina Kotsanas, Robyn Dever, Phillip Jones, Pam Koneçny, Richard Lawrence, David Rees, Suzanne Ryan, Michael P. Feneley, John Harkness, Phillip Jones, Suzanne Ryan, Phillip Jones, Suzanne Ryan, Phillip Jones, Jeffrey J. Post, Porl Reinbott, Suzanne Ryan, Rainer Gattringer, Franz Wiesbauer, Adriana Ribas Andrade, Ana Cláudia Passos de Brito, Armênio Costa Guimarães, Max Grinberg, Alfredo José Mansur, Rinaldo Focaccia Siciliano, Tânia Mara Varejão Strabelli, Marcelo Luiz Campos Vieira, Regina Aparecida de Medeiros Tranchesi, Marcelo Goulart Paiva, Cláudio Querido Fortes, Auristela de Oliveira Ramos, Clara Weksler, G. Ferraiuoli, W. Golebiovski, Cristiane da Cruz Lamas, James A. Karlowsky, Yoav Keynan, Andrew M. Morris, Ethan Rubinstein, Sandra Braun Jones, Patricia Muñoz García, Mauricio Cereceda, Alberto Fíca, Rodrigo Montagna Mella, Ricardo Fernández, Liliana Franco, Javier González, Astrid Natalia Jaramillo, Bruno Baršić, Suzana Bukovski, Vladimir Krajinović, Ana Pangerčić, Igor Rudež, Josip Vincelj, Tomáš Freiberger, Jiří Pol, Barbora Žaloudíková, Zainab Ashour, Amani El Kholy, Marwa Mishaal, Dina Osama, Hussien Rizk, N. Aissa, Corentine Alauzet, François Alla, Catherine Campagnac, Thanh Doco‐Lecompte, Christine Selton-Suty, J.-P. Casalta, Pierre‐Edouard Fournier, Gilbert Habib, Didier Raoult, Franck Thuny, François Delahaye, Armelle Delahaye, François Vandenesch, Erwan Donal, Pierre Yves Donnio, Erwan Flécher, C. Michelet, Matthieu Revest, Pierre Tattevin, Florent Chevalier, Antoine Jeu, Jean Paul Rémadi, Dan Ruşinaru, Christophe Tribouilloy, Yvette Bernard, Catherine Chirouze, Bruno Hoen, J. Leroy, Patrick Plésiat, Christoph Naber, Carl Neuerburg, Bahram Mazaheri, Christoph Naber, Carl Neuerburg, S. Athanasia, Ioannis Deliolanis, Helen Giamarellou, Θωμάς Τσαγανός, Efthymia Giannitsioti, Elena Mylona, O. Paniara, Konstantinos Papanicolaou, John Pyros, Athanasios Skoutelis, Elena Mylona, O. Paniara, Κωνσταντίνος Παπανικολάου, John Pyros, Athanasios Skoutelis, Gautam Sharma, Johnson Francis, Lathi Nair, Vinod Thomas, Krishnan Venugopal, Margaret M. Hannan, John P. Hurley, Maor Wanounou, Dan Gilon, Sarah Israel, Maya Korem, Jacob Strahilevitz, Ethan Rubinstein, Jacob Strahilevitz, Emanuele Durante‐Mangoni, Domenico Iossa, Serena Orlando, Maria Paola Ursi, Pia Clara Pafundi, Fabiana D’Amico, Mariano Bernardo, Susanna Cuccurullo, Giovanni Dialetto, Franco Enrico Covino, Sabrina Manduca, Alessandro Della Corte, Marisa De Feo, Marie Françoise Tripodi, Enrico Cecchi, Francesco Giuseppe De Rosa, Davide Forno, Massimo Imazio, Rita Trinchero, Paolo Grossi, Mariangela Lattanzio, Antonio Toniolo, Antonio Goglio, Annibale Raglio, Veronica Ravasio, Marco Rizzi, Fredy Suter, Giampiero Carosi, Silvia Magri, Liana Signorini, Zeina A. Kanafani, Souha S. Kanj, Ahmad Sharif-Yakan, Imran Zainal Abidin, Syahidah Syed Tamin, Eduardo Rivera Martínez, Gabriel Israel Soto Nieto, Jan T. M. van der Meer, Stephen T. Chambers, David Holland, Arthur Morris, Nigel Raymond, Kerry Read, David Murdoch, Stefan I. Dragulescu, Adina Ionac, Cristian Mornoş, O. M. Butkevich, Н. С. Чипигина, Ozerecky Kirill, Kulichenko Vadim, Tatiana Vinogradova, Jameela Edathodu, Magid Halim, Yee‐Yun Liew, Ru‐San Tan, Tatjana Lejko-Zupanc, Mateja Logar, Manica Mueller‐Premru, Patrick Commerford, Anita Commerford, Eduan Deetlefs, Cass Hansa, Mpiko Ntsekhe, Manel Almela, Juan Ambrosioni, Manuel Azqueta, Merçè Brunet, Pedro Castro, Elisa de Lazzari, Carlos Falces, David Fuster, Guillermina Fita, Cristina García de la Mària, Javier García‐González, José M. Gatell, Jaume Llopis, Francesc Marco, José M. Miró, Asunción Moreno, José Ortíz, Salvador Pié i Ninot, JC Paré, Juan M. Pericàs, Eduard Quintana, José Ramírez, Irene Rovira, Elena Sandoval, Marta Sitges, Adrián Téllez, José M Tolosana, Bárbara Vidal, Jordi Vilà, Ignasi Anguera, Bernat Font, Joan Raimón Gumà, Javier Bermejo, Emilio Bouza, Miguel Ángel García Fernández, Víctor José González Ramallo, Mercedes Marín, Patricia Muñóz, Miguel Pedromingo, J. Roda, Marta Rodríguez‐Créixems, Jorge Solı́s, Benito Almirante, Nuria Fernández‐Hidalgo, Pilar Tornos, Arístides de Alarcón, Ricardo Parra, Eric Alestig, Magnus Johansson, Lars Olaison, Ulrika Snygg‐Martin, Orathai Pachirat, Pimchitra Pachirat, Burabha Pussadhamma, Vichai Senthong, Anna Casey, Tom Elliott, Peter A. Lambert, Richard Watkin, Christina Eyton, John L. Klein, Suzanne Bradley, Carol A. Kauffman, Roger Bedimo, Vivian H. Chu, G. Ralph Corey, Anna Lisa Crowley, Pamela S. Douglas, Laura Drew, Vance G. Fowler, Thomas L Holland, Tahaniyat Lalani, Daniel W. Mudrick, Zaniab Samad, Daniel J. Sexton, Martín E. Stryjewski, Andrew Wang, Christopher W. Woods, Stamatios Lerakis, Robert Cantey, Lisa L. Steed, Dannah Wray, Stuart A. Dickerman, Hector Bonilla, Joseph R. DiPersio, Sara‐Jane Salstrom, John W. Baddley, Mukesh Patel, Gail Peterson, Amy Stancoven, Donald P. Levine, Jonathan Riddle, Michael J. Rybak, Christopher H. Cabell, Mohamed Abdel‐Wahab, Alexandre Abizaid, GuglielmoMario Actis Dato, Fernándo Alfonso, Abdullah Alkhodair, Alberto Alperi, Ignacio J. Amat‐Santos, Júlio Andrea, Vincent Auffret, Marco Barbanti, Antonio L. Bartorelli, Marouane Boukhris, Francisco Campelo‐Parada, Juan C. Castillo, Tarun Chakravarty, Chekrallah Chamandi, Asim N. Cheema, Alexandre Siciliano Colafranceschi, Valter Correia de Lima, Lisa Crusius, David del Val, Éric Durand, Hélène Eltchaninoff, Vinícius Esteves, Maria Cristina Meira Ferreira, Claudia Fiorina, Philippe Gervais, Francesco Giannini, Roger Renault Godinho, Enrique Gutiérrez, Rosana Hernández‐Antolín, Howard C Herrmann, Dominique Himbert, David Holzhey, Zenon Huczek, Oliver Hüsser, Nikolaj Ihlemann, Samir Kapadia, Utz Kappert, Won-Keun Kim, Annapoorna Kini, Susheel Kodali, Martin Landt, Azeem Latib, Hervé Breton, Axel Linke, John Lisko, Ugolino Livi, Frédéric Maes, Raj Makkar, José Armando Mangione, Norman Mangner, Marcos Maynar-Mariño, Jean‐Bernard Masson, Antonio Miceli, Érika Muñoz-García, Luis Nombela‐Franco, Paolo Olivares, Vassili Panagides, Isaac Pascual, Ander Regueiro, Henrique Barbosa Ribeiro, Josep Rodés‐Cabau, Rafael Romaguera, Francesco Rosato, Luisa Salido Tahoces, Fábio Sândoli de Brito, Piotr Ścisło, Vicenç Serra, Clément Servoz, Saif Siddiqui, Jan Malte Sinning, Lars Søndergaard, Sandro Sponga, Stefan Stortecky, Didier Tchétché, Luca Testa, Marina Ureña, Victòria Vilalta, John Webb, Harindra C. Wijeysundera - Clinical Infectious Diseases 2023 cited by 32

BACKGROUND: Scarce data are available comparing infective endocarditis (IE) following surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR). This study aimed to compare the clinical presentation, microbiological profile, management, and outcomes of IE after SAVR versus TAVR. METHODS: Data were collected from the "Infectious Endocarditis after TAVR International" (enrollment from 2005 to 2020) and the "International Collaboration on Endocarditis" (enrollment from 2000 to 2012) registries. Only patients with an IE affecting the aortic valve prosthesis were included. A 1:1 paired matching approach was used to compare patients with TAVR and SAVR. RESULTS: A total of 1688 patients were included. Of them, 602 (35.7%) had a surgical bioprosthesis (SB), 666 (39.5%) a mechanical prosthesis, 70 (4.2%) a homograft, and 350 (20.7%) a transcatheter heart valve. In the SAVR versus TAVR matched population, the rate of new moderate or severe aortic regurgitation was higher in the SB group (43.4% vs 13.5%; P < .001), and fewer vegetations were diagnosed in the SB group (62.5% vs 82%; P < .001). Patients with an SB had a higher rate of perivalvular extension (47.9% vs 27%; P < .001) and Staphylococcus aureus was less common in this group (13.4% vs 22%; P = .033). Despite a higher rate of surgery in patients with SB (44.4% vs 27.3%; P < .001), 1-year mortality was similar (SB: 46.5%; TAVR: 44.8%; log-rank P = .697). CONCLUSIONS: Clinical presentation, type of causative microorganism, and treatment differed between patients with an IE located on SB compared with TAVR. Despite these differences, both groups exhibited high and similar mortality at 1-year follow-up.