Subcutaneous delivery of FGF21 mRNA therapy reverses obesity, insulin resistance, and hepatic steatosis in diet-induced obese mice

Authors: Stefano Bartesaghi, Kristina Wallenius, Daniel Hovdal, Mathias Liljeblad, Simonetta Wallin, Niek Dekker, Louise Barlind, Nigel Davies, Frank Seeliger, Maria Sörhede Winzell, Sima Patel, Matt Theisen, Luis Brito, Nils Bergenhem, Shalini Andersson, Xiaorong Peng - Molecular Therapy — Nucleic Acids 2022 cited by 38

. This study is the first example of s.c. mRNA therapy showing pre-clinical efficacy in a disease-relevant model, thus, showing the potential for this modality in the treatment of chronic diseases, including T2D and NASH.