Effectiveness and tolerability of dolutegravir/lamivudine for the treatment of HIV-1 infection in clinical practice

Authors: Inés Suárez‐García, Belén Alejos, Víctoria Hernando, Laura Viñuela, Mar Vera García, David Rial‐Crestelo, Marı́a Jesús Pérez-Elı́as, Helena Iglesias, Joaquim Peraire, Juan Tiraboschi, Asunción Díaz, Santiago Moreno, Inmaculada Jarrín, Santiago Moreno, Inmaculada Jarrín, David Dalmau, Marta Navarro, Maria Gonzalez, Féderico García, Eva Poveda, José Antonio Iribarren, Félix Gutiérrez, Rafael Rubio, Francesc Vidal, Juan Berenguer, Juan González, María Ángeles Muñoz‐Fernández, Inmaculada Jarrín, Cristina Moreno, Marta Rava, Rebeca Izquierdo, Jorge del Romero Raposo, Cristina Marco, Julián Puente, María Ángeles Muñoz‐Fernández, Elba Mauleón, Roxana Juárez, Joaquín Portilla, Irene Portilla, Esperanza Merino, Gema García, Iván Agea, José Sánchez–Payá, Juan Carlos Rodrı́guez, Livia Giner, Sergio Reus, Vicente Boix, Diego Torrús, Verónica Pérez, Julia Portilla, María Remedios Alemán Valls, Jehovana Hernández, Ana López Lirola, Dácil García, Felícitas Díaz-Flores, M. Mar Alonso, Ricardo Pelazas, Víctor Asensi, M Eugenia Rivas, Tomás Suárez‐Zarracina, Eulalia Valle-Garay, Javier Arias‐Díaz, Federico Pulido, Rafael Rubio, Otilia Bisbal, M. Asunción Hernando, David Rial, María Lagarde, Octavio Arce, Adriana Pinto, Laura Muñoz Bermejo, Mireia Santacreu, Roser Navarro, Candela Gonzalez, José Antonio Iribarren, María José Aramburu, Xabier Camino, Miguel Ángel von Wichmann, Miguel Ángel Goenaga, Ma Jesús Bustinduy, Harkaitz Azkune, Maialen Ibarguren, Xabier Kortajarena, Ignacio Álvarez-Rodriguez, Leire Gil, Lourdes Martínez, Félix Gutiérrez, Mar Masiá, Catalina Robledano, Sergio Padilla, Javier García Abellán, Paula Mascarell, Araceli Adsuar, Rafael J. Pascual, Mar Carvajal, Marta Fernández, José Alberto García, Ángela Botella, Alba de la Rica, Carolina Ding, Lidia García-Sánchez, Nuria Ena, Xavier Barber, Vanessa Agullo, Reyes Pascual, Guillermo Telenti, Lucía Guillén, Leandro López, Jennifer Vallejo, Nieves Gonzalo-Jiménez, Montserrat Ruiz, Antonio Galiana, Roberto Muga, Arantza Sanvisens, Daniel Fuster, Juan Carlos López Bernaldo de Quirós, Isabel Gutiérrez, Margarita Ramírez, Belén Padilla, Paloma Gijón, Teresa Aldámiz‐Echevarría, Francisco Tejerina, Cristina Díez, Leire Pérez, Chiara Fanciulli, Saray Corral, Joaquín Peraire, Anna Martí, Consuelo Viladés, Montserrat Vargas, Montserrat Olona, Anna Rull, Verònica Alba, Elena Yeregui, Jenifer Masip, Graciano García‐Pardo, Fréderic Gómez-Bertomeu, Sonia Espineira, Marta Montero, Marino Blanes, María Tasias, Eva Calabuig, Miguel Salavert, Juan Fernández, Inmaculada Segarra, Juan González‐García, Ana Delgado‐Hierro, José Ramón Arribas, Víctor Arribas, José Ignacio Bernardino, Carmen Busca, Joanna Cano, Julen Cadiñanos, Juan Castro, Luis Escosa, Iker Falces, Pedro Herranz, Víctor Hontañón, Milagros García, Alicia González, Luz Martín‐Carbonero, Mario Mayoral, Ma José Mellado, Rafael Micán, Rosa de Miguel, Rocío Montejano, Marisa Montes, V. Moreno, Luis Ramos Berta Rodés, Talía Sainz, Elena Sendagorta, Eulalia Valencia, José Ramón Blanco, Laura Pérez‐Martínez, José A. Oteo, Valvanera Ibarra, Luís Metola, Mercedes Sanz, Rosa Martı́nez, Gloria Sampériz, David Dalmau, Marina Martínez, Ángeles Jaén, Mireia Cairó, Javier Martinez-Lacasa, Roser Font, Laura Gisbert, María Rivero, Beatriz Piérola, Maider Goikoetxea, María Pilar Rivero Gracia, Carlos Ibero, Estela Moreno, Jesús Repáraz, Gemma Navarro, Manel Cervantes Garcia, Sonia Calzado Isbert, Marta Navarro Vilasaró, Belen Lopez Garcia, Ignacio de los Santos, Alejandro de los Santos, Jesús Sanz, Lucio García‐Fraile, Enrique García Martín, Ildefonso Sánchez‐Cerrillo, Marta Calvet, Ana Barrios, Azucena Bautista, Carmen Sáez, Marianela Ciudad, Ángela Gutiérrez, Santiago Moreno, Santos del Campo, José L. Casado, Fernando Dronda, Ana Moreno, María Jesús Pérez-Granda, Sergio E. Serrano, María Jesús Vivancos, Javier Martínez‐Sanz, Alejandro Vallejo, Matilde Sanchez, José A. Pérez‐Molina, José Manuel Hermida, Enrique Bernal, Antonia Alcaraz, Joaquín Bravo, Ángeles Muñoz, C. Tomás, Mónica Martínez, M. Carmen Villalba, Féderico García, Clara Martínez, José Hernández, Leopoldo Muñoz Medina, Marta Álvarez, Natalia Chueca, David Vinuesa, Adolfo de Salazar, Ana Fuentes, Emilio Guirao, Laura Viñuela, Andrés Ruiz-Sancho, Francisco Anguita, Jorge Del Romero, Montserrat Raposo, Carmen Rodríguez, Teresa Puerta, Juan Carlos Carrió, Mar Vera, Juan Ballesteros, Oskar Ayerdi, Begoña Baza, Eva Orviz, Antonio Antela, Elena Losada, Melchor Riera, María Luz Pintos Peñaranda, Ma Angels Ribas, Antoni A Campins, Mercedes Garcia-Gazalla, Francisco Fanjul, Javier Murillas, Francisco Homar, Helem Vílchez, Luisa Martín, Antoni Payeras, Jesús Santos, María López, Cristina Gómez, Isabel Viciana, Rosario Palacios, Luís F. López‐Cortés, Núria Espinosa, Cristina Roca, Silvia Llaves, Juan Tiraboschi, Arkaitz Imaz, Ana Karina Silva, María Saumoy, Sofía Catalina Scévola, Adrián Curran, Vicenç Falcó, Jordi Navarro, Joaquín Burgos, Paula Suanzes, Jorge García, Vicente Descalzo, Patricia Álvarez, Bibiana Planas, Marta Sanchíz, Lucía Rodríguez, Julián Olalla, Matilde Sanchez, Javier Pérez, Alfonso del Arco, Javier de la Torre, José Luís Prada, Onofre Juan Martínez, Lorena Martinez‐Gamboa, Francisco Jesús Vera, Josefina García, Begoña Alcaraz, A. Guirao, Álvaro Mena, Ángeles Castro, Berta Pernas, Pilar Vázquez, Soledad López, Sofía Ibarra, Guillermo García, Josu Mirena, Oscar Luis Ferrero, Josefina López, Margarita Cámara, Mireia de la Peña, Miriam Lopez, Iñigo López, Itxaso Lombide, Víctor Polo, Joana Miguel, Carlos Galera, Marian Fernández, Helena Albendín, Antonia Navas Castillo, Asunción Iborra, Antonio Moreno, Maria Angustias Merlos, Asunción Vidal, Concha Amador, Francisco Pasquau, Concepción Gil, José Tomás Algado, Inés Suárez‐García, Eduardo Malmierca, Patricia González‐Ruano, Montserrat Ruiz, José Francisco Pascual, Luz Balsalobre, Ángela Somodevilla, Marcela Lopez, Mohamed Omar, Carmen Herrero, M Amparo Gómez, Miguel Alberto de Zárraga, Desiré Pérez, Vicente Estrada, Nieves Sanz, Noemí Cabello, Jorge Vergas, M Jose Núñez, Íñigo Sagastagoitia, Reynaldo Homen, Ana Muñoz, Miguel Górgolas, Alfonso Cabello, Beatriz Álvarez, Laura Lorente Prieto, Irene Carrillo, Aws Al‐Hayani, José Sanz, Alberto Arranz, Cristina Hernández, María Novella, Marı́a José Galindo, Ana Ferrer, Antonio Rivero Román, Inma Ruíz, Antonio Rivero Juárez, Pedro López López, Isabel Machuca, Mario Frías, Ángela Camacho, Ignacio Pérez, Diana Corona, Ignacio Pérez, Diana Corona, Miguel Cervero, Rafael Torres, Juan Macías Sánchez, Pilar Rincón, Luís Miguel Real, Anaïs Corma, Marta Fernández, Alejandro González‐Serna, Eva Poveda, Alexandre Pérez‐González, Luís Morano, Celia Miralles, Antonio Ocampo, Guillermo Pousada, Lucía Patiño, Carlos Dueñas, Sara Gutiérrez, Elena Tapia, Cristina Novoa, Xjoylin Egües, Pablo Telleria - Journal of Antimicrobial Chemotherapy 2023 cited by 34

OBJECTIVES: To assess the effectiveness and tolerability of dolutegravir (DTG)/lamivudine (3TC) among treatment-naive and virologically suppressed treatment-experienced individuals in the multicentre cohort of the Spanish HIV/AIDS Research Network (CoRIS) during the years 2018-2021. METHODS: We used multivariable regression models to compare viral suppression (VS) [HIV RNA viral load (VL) <50 copies/mL] and the change in CD4 cell counts at 24 and 48 (±12) weeks after initiation with dolutegravir/lamivudine or other first-line ART regimens. RESULTS: We included 2160 treatment-naive subjects, among whom 401 (18.6%) started with dolutegravir/lamivudine. The remaining subjects started bictegravir (BIC)/emtricitabine (FTC)/tenofovir alafenamide (TAF) (n = 949, 43.9%), DTG + FTC/tenofovir disoproxil fumarate (TDF) (n = 282, 13.1%), DTG/3TC/abacavir (ABC) (n = 255, 11.8%), darunavir (DRV)/cobicistat(COBI)/FTC/TAF (n = 147, 6.8%) and elvitegravir (EVG)/COBI/FTC/TAF (n = 126, 5.8%). At 24 and 48 weeks after starting dolutegravir/lamivudine, 91.4% and 93.8% of the subjects, respectively, achieved VS. The probability of achieving VS with dolutegravir/lamivudine was not significantly different compared with any other regimen at 24 or 48 weeks, with the exception of a lower chance of achieving VS at 24 weeks for DRV/COBI/FTC/TAF (adjusted OR: 0.47; 95% CI: 0.30-0.74) compared with dolutegravir/lamivudine.For the analysis of treatment-experienced virally suppressed subjects we included 1456 individuals who switched to dolutegravir/lamivudine, among whom 97.4% and 95.5% maintained VS at 24 and 48 weeks, respectively. During the first 48 weeks after dolutegravir/lamivudine initiation, 1.0% of treatment-naive and 1.5% of treatment-experienced subjects discontinued dolutegravir/lamivudine due to an adverse event. CONCLUSIONS: In this large multicentre cohort, effectiveness and tolerability of dolutegravir/lamivudine were high among treatment-naive and treatment-experienced subjects.