Depression and anxiety in patients with active ulcerative colitis: crosstalk of gut microbiota, metabolomics and proteomics

Authors: Xiaomin Yuan, Biqing Chen, Zhenglan Duan, Ziqian Xia, Yang Ding, Tuo Chen, Huize Liu, Baosheng Wang, Bolin Yang, Xiaoyong Wang, Shijia Liu, Jin‐Yong Zhou, Yajun Liu, Qiong Wang, Zhaofeng Shen, Jun Xiao, Hongtao Shang, Weiwei Liu, Guo‐Ping Shi, Lei Zhu, Yugen Chen - Gut Microbes 2021 cited by 265

. Most metabolites (e.g., glycochenodeoxycholate) were increased in the serum, while few metabolites, including 2'-deoxy-D-ribose and L-pipecolic acid, were decreased, accompanied by a general reduction in immunoglobulin proteins. These related bacteria, metabolites, and proteins were highly connected. A prophylactic administration of 2'-deoxy-D-ribose and L-pipecolic acid significantly reduced the depressive-like behaviors in mice with colitis and alleviated the inflammatory cytokine levels in their colon, blood and brain. This study has identified a comprehensive multi-omics network related to depression and anxiety in active UC. It is composed of a certain set of gut microbiota, metabolites, and proteins, which are potential targets for clinical intervention for patients with UC and depression/anxiety.