Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy

Authors: Yao‐Chung Liu, Junsu Kwon, Emiliano Fabiani, Zhijian Xiao, Yanjing V. Liu, Matilde Y. Follo, Jinqin Liu, Huijun Huang, Chong Gao, Jun S. Liu, Giulia Falconi, Lia Valentini, Carmelo Gurnari, Carlo Finelli, Lucio Cocco, Liu H, Adrianna I. Jones, Junyu Yang, Henry Yang, Julie A.I. Thoms, Ashwin Unnikrishnan, John E. Pimanda, Rongqing Pan, Mahmoud A. Bassal, Maria Teresa Voso, Daniel G. Tenen, Li Chai - New England Journal of Medicine, NEJM 2022 cited by 62

BACKGROUND: Although hypomethylating agents are currently used to treat patients with cancer, whether they can also reactivate and up-regulate oncogenes is not well elucidated. METHODS: expression. RESULTS: expression. CONCLUSIONS: By combining analysis of patient samples with CRISPR-DiR technology, we found that demethylation and up-regulation of an oncogene after treatment with a hypomethylating agent can indeed occur and should be further studied. (Funded by Associazione Italiana per la Ricerca sul Cancro and others.).