Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation

Authors: Yunpeng Zhao, Cheng Qiu, Wenhan Wang, Jiangfan Peng, Xiang Cheng, Yangtao Shangguan, Mingyang Xu, Jiayi Li, Ruize Qu, Xiaomin Chen, Suyi Jia, Dan Luo, Long Liu, Peng Li, Fengjin Guo, Krasimir Vasilev, Liang Liu, John D. Hayball, Shuli Dong, Xin Pan, Yuhua Li, Linlin Guo, Lei Cheng, Weiwei Li - Theranostics 2020 cited by 160

This study suggests the role of CST in mitochondrial ROS and activation of the NLRP3 inflammasome in IVD degeneration, which might shed light on therapeutic targets for IVD degeneration.