Circular RNAs in and out of Cells: Therapeutic Usages of Circular RNAs

Authors: Mingyu Ju, Dayeon Kim, Geurim Son, Jinju Han - Molecules and Cells 2023 cited by 26

. Depending on the purpose, synthetic circular RNA sequences can either be identical to endogenous circular RNA sequences or artificially designed. In this review, we introduce the life cycle and known functions of intracellular circular RNAs. The current stage of endogenous circular RNAs as biomarkers and therapeutic targets is also described. Finally, approaches and considerations that are important for applying the available knowledge on endogenous circular RNAs to design exogenous circular RNAs for therapeutic purposes are presented.