PD-1H (VISTA)–mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus

Authors: Xue Han, Matthew D. Vesely, Wendy Yang, Miguel F. Sanmamed, Ti Badri, Jude Alawa, Francesc López‐Giráldez, Patricia Gaule, Sang Won Lee, Jianping Zhang, Xinxin Nie, Ala F. Nassar, Agedi Boto, Dallas B. Flies, Linghua Zheng, Tae Kon Kim, Gilbert Moeckel, Jennifer M. McNiff, Lieping Chen - Science Translational Medicine 2019 cited by 131

mice reduces cutaneous disease, autoantibodies, inflammatory cytokines, chemokines, and immune cell expansion. Furthermore, PD-1H on both T cells and myeloid cells including neutrophils and pDCs could transmit inhibitory signals, resulting in reduced activation and function, establishing PD-1H as an inhibitory receptor on T cells and myeloid cells. On the basis of these findings, we propose that PD-1H is a critical element in the pathogenesis and progression of lupus, and PD-1H activation could be effective for treatment of systemic and cutaneous lupus.