GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats

Authors: Samantha M. Fortin, Rachele K. Lipsky, Rinzin Lhamo, Jack Chen, Eun Kyung Kim, Tito Borner, Heath D. Schmidt, Matthew R. Hayes - Science Translational Medicine 2020 cited by 133

transcripts in NTS GABAergic neurons, which when inhibited using chemogenetics, attenuated the food intake- and body weight-reducing effects of liraglutide. This work demonstrates the contribution of NTS GLP-1Rs to the anorectic potential of liraglutide and highlights a phenotypically distinct (GABAergic) population of neurons within the NTS that express the GLP-1R and are involved in the mediation of liraglutide signaling.