MMP1/PAR1/SP/NK1R paracrine loop modulates early perineural invasion of pancreatic cancer cells

Authors: Chumei Huang, Yaqing Li, Yubo Guo, Z. Zhang, Guoda Lian, Yinting Chen, Jian Li, Yonghui Su, Jiajia Li, Kege Yang, Shaojie Chen, Hong Su, Kaihong Huang, Linjuan Zeng - Theranostics 2018 cited by 105

In this study, we provided evidence that the MMP1/PAR1/SP/NK1R paracrine loop contributes to PNI during the early stage of primary tumor formation. Furthermore, we established a sensitive and non-invasive method to detect nerve invasion using iron oxide nanoparticles and MRI.