High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling

Authors: De Xie, Hairong Zhao, Jiaming Lu, Furong He, Weidong Liu, Wei Yu, Qiang Wang, Ichiro Hisatome, Tetsuya Yamamoto, Hidenori Koyama, Jidong Cheng - American Journal of Physiology-Endocrinology and Metabolism 2021 cited by 137

Hyperuricemia and nonalcoholic fatty liver disease are global public health problems, which are strongly associated with metabolic syndrome. In this study, we demonstrate that uric acid induces hepatic fat accumulation via the ROS/JNK/AP-1 pathway. This study identifies a new mechanism of NAFLD pathogenesis and new potential therapeutic strategies for HUA-induced NAFLD.