Transcriptional profiles of adjuvanted hepatitis B vaccines display variable interindividual homogeneity but a shared core signature

Authors: Laurane De Mot, Viviane Bechtold, Vanesa Bol, Andrea Callegaro, Margherita Coccia, Ahmed Essaghir, Dicle Hasdemir, Fernando Ulloa‐Montoya, Emilio Siena, Age K. Smilde, Robert A. van den Berg, Arnaud M. Didierlaurent, Wivine Burny, Robbert van der Most - Science Translational Medicine 2020 cited by 67

-adjuvanted vaccine was linked to its ability to induce this signature in most vaccinees even after the first vaccination. Therefore, our data suggest that adjuvanticity is not strictly defined by the nature of the receptors or signaling pathways it activates but by the ability of the adjuvant to consistently induce a core inflammatory signature across individuals.