Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes

Feng Zhou; Jingtian Mei; Xiuguo Han; Hanjun Li; Shengbing Yang; Minqi Wang; Linyang Chu; Han Qiao; Tingting Tang

doi:10.1016/j.apsb.2019.01.015

Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes

Authors: Feng Zhou, Jingtian Mei, Xiuguo Han, Hanjun Li, Shengbing Yang, Minqi Wang, Linyang Chu, Han Qiao, Tingting Tang - Acta Pharmaceutica Sinica B 2019 cited by 408

, Kin reduced the infiltration of M1 macrophages, promoted M2 macrophages in the synovium, inhibited subchondral bone destruction and reduced articular cartilage damage induced by ACLT. All the results indicated that Kin is an effective therapeutic candidate for OA treatment.