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Development of hypoxia-activated PROTAC exerting a more potent effect in tumor hypoxia than in normoxia

Authors: Weiyan Cheng, Shasha Li, Xueqian Wen, Siyuan Han, Suhua Wang, Wei Han, Zhizhen Song, Yueqin Wang, Xin Tian, Xiaojian Zhang - Chemical Communications 2021 cited by 118

in hypoxia than in normoxia in HCC4006 cells. This is the first example of identifying a PROTAC to selectively act on tumors utilizing the characteristic of tumor hypoxia and provides a new approach for PROTAC development.

Development of hypoxia-activated PROTAC exerting a more potent effect in tumor hypoxia than in normoxia | Litlas