Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study

Authors: Tamir Kanias, Marion C. Lanteri, Grier P. Page, Yuelong Guo, Stacy Endres‐Dighe, Mars Stone, Sheila M. Keating, Alan E. Mast, Ritchard G. Cable, Darrell J. Triulzi, Joseph E. Kiss, Edward L. Murphy, Steve Kleinman, Michael P. Busch, Mark T. Gladwin - Blood Advances 2017 cited by 223

< .0001). Donor race/ethnicity was also associated with extreme (>1%) levels of storage hemolysis exceeding US Food and Drug Administration regulations for transfusion (hemolysis >1% was observed in 3.51% of Asian and 2.47% of African American donors vs 1.67% of white donors). These findings highlight the impact of donor genetic traits on measures of RBC hemolysis during routine cold storage, and they support current plans for genome-wide association studies, which may help identify hereditable variants with substantive effects on RBC storage stability and possibly posttransfusion outcomes.