Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys

Authors: Sheng Zhao, Wei Li, Weimin Yu, Ting Rao, Haoyong Li, Yuan Ruan, Run Yuan, Chenglong Li, Jinzhuo Ning, Siqi Li, Chen Wu, Cheng Fan, Xiangjun Zhou - Theranostics 2021 cited by 169

Our findings reveal that exosomal miR-21 from tubular epithelial cells may accelerate the development of renal fibrosis by activating fibroblasts via the miR-21/PTEN/Akt pathway in obstructed kidneys.