Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial

Authors: PK Judge, Natalie Staplin, KJ Mayne, Christoph Wanner, Julie Green, SJ Hauske, Jonathan Emberson, David Preiss, SYA Ng, AJ Roddick, Emily Sammons, Dandan Zhu, Michael Hill, W. Grant Stevens, Karl Wallendszus, Susanne Brenner, AK Cheung, Zhihong Liu, J Li, LS Hooi, Wenjun Liu, Takashi Kadowaki, Masaomi Nangaku, Adeera Levin, David Z.I. Cherney, Aldo P. Maggioni, Roberto Pontremoli, Rajat Deo, Shinichi Goto, Xavier Rosselló, Katherine R. Tuttle, Dominik Steubl, Daisy Massey, Martin Landray, Colin Baigent, Richard Haynes, WG Herrington, S Abat, Riaz Rahman, Rizna Abdul Cader, MI Abdul Hafidz, MZ Abdul Wahab, NK Abdullah, Talal Abdulsamad, Masanori Abe, Nader G. Abraham, Sarah Acheampong, P Achiri, JA Acosta, A. Q. Adeleke, Vicki Adell, R Adewuyi-Dalton, Nihad Adnan, A Africano, Mohsen Agharazii, Frank G. Aguilar, A Aguilera, Movahedian Ahmad, MK Ahmad, NA Ahmad, NH Ahmad, NI Ahmad, Norazinizah Ahmad Miswan, H Ahmad Rosdi, Iffat Ahmed, Sofia B. Ahmed, Sofia B. Ahmed, Joan Aiello, A. Aitken, R AitSadi, Sendogan Aker, S Akimoto, A Akinfolarin, S. Akram, Federico Alberici, Christian Albert, Leslie N. Aldrich, M Alegata, Lee Alexander, S Alfaress, Mohammad Alhadj Ali, Ahmed Issam Ali, Ahmed Issam Ali, Radica Z. Alicic, A Aliu, Ricardo López Almaraz, Rashid Almasarwah, Jussara Carnevale de Almeida, Alessia Aloisi, Laith Al‐Rabadi, Mark Dominik Alscher, Pedro Álvarez, Bader Al-Zeer, Mora Amat, Christopher S. Ambrose, Hany Ammar, Yu An, L Andriaccio, Kwame Ansu, A Apostolidi, N. Arai, Hiroaki Araki, Shin‐ichi Araki, A Arbi, O Arechiga, Sarah Armstrong, Taylor J. Arnold, S Aronoff, W Arriaga, Jorge G. Arroyo, Daniel Arteaga, Shingo Asahara, Akira Asai, N Asai, S Asano, M Asawa, M.F. Asmee, Filippo Aucella, Marc Augustin, Anthony Avery, Ahmed K. Awad, IY Awang, Motoharu Awazawa, A Axler, W Ayub, Zaid Azhari, Rocco Baccaro, C Badin, Benjamin M. Bagwell, E Bahlmann-Kroll, AZ Bahtar, Colin Baigent, Diksha Bains, Harpreet S. Bajaj, Rebecca Baker, Enke Baldini, Bernhard Banas, Debasish Banerjee, Shogo Banno, Shweta Bansal, Simona Barberi, Stephen L. Barnes, Cecilia Barnini, C Barot, Kim E. Barrett, R Barrios, B Bartolomei Mecatti, I Barton, Janet Barton, W Basily, Sunita Bavanandan, Alex Baxter, Lewis C. Becker, Srinivasan Beddhu, Joachim Beige, S.A. Beigh, Samira Bell, Urs Benck, Amanda Beneat, Aisleen Bennett, David Bennett, Sarah Benyon, Jocelyn Berdeprado, Tobias Bergler, Albrecht Bergner, Marla J. Berry, Micheli Bevilacqua, J Bhairoo, Sudhir Bhandari, Netra Prakash Bhandary, Ankeet S. Bhatt, Mukul Bhattarai, Mansi Bhavsar, W Bian, Francesca Bianchini, Salvatore Lo Bianco, R. W. Bilous, Jennifer Bilton, Donatella Bilucaglia, C Bird, Divya Birudaraju, M Biscoveanu, Christine E. Blake, Nina Bleakley, K Bocchicchia, Sue C. Bodine, Richard Bodington, Simone Cosima Boedecker-Lips, Marie-Ève Bolduc, Shaun Bolton, Christopher Bond, Fadia El Boreky, Kenneth Boren, Ryotaro Bouchi, Laura Bough, Danijela Bovan, Chris Bowler, Louise Bowman, Navdeep Brar, C. Braun, A Breach, M. Breitenfeldt, Susanne Brenner, Brian Brettschneider, A Brewer, George J. Brewer, V Brindle, Elena Brioni, Christopher Brown, Heather A. Brown, Louise Brown, R. H. Brown, Simon Brown, Duncan L. Browne, K Bruce, Martina Brueckmann, Nigel J. Brunskill, Maria Bryant, Małgorzata M. Brzóska, Yang Bu, Cierra Buckman, Matthew J. Budoff, Michael Bullen, Andy Burke, Shane Burnette, Claire Burston, Martin Busch, John Bushnell, Sara K. Butler, Janine Büttner, Christopher D. Byrne, A Caamano, J Cadorna, Cesira Cafiero, Marianna P. Cagle, Jianwen Cai, Kátia da Silva Calabrese, Carla L. Calvi, Brian Camilleri, S Camp, Danielle Campbell, Ryan Campbell, Hongying Cao, Irene Capelli, M Caple, Ben Caplin, A Cardone, J Carle, V Carnall, Maurizio Caroppo, Sue Carr, Gianni Carraro, Michael W. Carson, P. Casares, Carmen E. Castillo, Cynthia M. Castro, Barry D. Caudill, Vladimir Cejka, Martina Ceseri, Leslie Cham, Alanna M. Chamberlain, Jonathan Chambers, CBT Chan, JYM Chan, YC Chan, Emily Chang, Emily Chang, Terri Chant, T Chavagnon, P Chellamuthu, Fei Chen, Jing Chen, Pau‐Chung Chen, TM Chen, Y Chen, Y Chen, Cailian Cheng, Hong Cheng, MC Cheng, David Z.I. Cherney, AK Cheung, CH Ching, Nihil Chitalia, Rushab Choksi, Charles Nnanna Chukwu, Kevin K. Chung, Giuseppe Cianciolo, L Cipressa, Sarah L. Clark, Harry S. Clarke, Robert Clarke, Samantha Clarke, B. T. Cleveland, Edward Cole, H Coles, L Condurache, Andrew Connor, Karen Convery, Angela Cooper, Nichola Cooper, Zara Cooper, Leslie Cooperman, Linda Cosgrove, Patricia Coutts, Allen W. Cowley, Rachel Craik, Guanglin Cui, T Cummins, Neera K. Dahl, Hui Dai, Lorraine H. Dajani, Anthony M. D’Amelio, E Damian, K Damianik, Laurence Danel, Curt J. Daniels, T. Daniels, S Darbeau, H Darius, Tanaji Dasgupta, Justin H. Davies, Louise Davies, Adrienne L. Davis, Joshua S. Davis, Leslie L. Davis, R. Dayanandan, Sabriye Dayı, R Dayrell, Luca De Nicola, Subrata Debnath, Wissam Deeb, Stefan Degenhardt, K DeGoursey, Michael P. Delaney, Rajat Deo, Roger DeRaad, Vimal K. Derebail, Donovan A. Dev, M.A. Devaux, P Dhall, Gundeep Dhillon, J Dienes, Mirela Dobre, Eunice Doctolero, V Dodds, D. Domingo, Denise Donaldson, Peter T. Donaldson, C Donhauser, Vicki Donley, S Dorestin, S Dorey, Timothy Doulton, D Draganova, K Draxlbauer, F Driver, Hai Du, F. Dubé, Tim Duck, Tabinda Dugal, Julien Dugas, Hari Dukka, Hubert Dumann, W. B. Durham, Martin Dürsch, R Dykas, R Easow, E Eckrich, Gabriele Eden, Exodus Edmerson, Hannah B Edwards, LW Ee, Jun Eguchi, Yvonne Ehrl, Kerstin Eichstädt, William Eid, Bradley Eilerman, Yasuo Ejima, H Eldon, Timothy Ellam, Lawrence Elliott, Richard T. Ellison, Jonathan Emberson, Riley Epp, Ayşe Er, M Espino-Obrero, Stephanie Estcourt, Luca Estienne, Gregory W. Evans, Jonathan Evans, Simon Evans, Gianna Fabbri, M Fajardo-Moser, Colomba Falcone, Fereshteh Fani, P Faria-Shayler, Farahnaz Farnia, David Farrugia, Mirjam Fechter, D. Fellowes, F Feng, Cornelius James Fernandez, Pietro Manuel Ferraro, Andrew Field, Sameh Fikry, J Finch, Harrison T. Finn, Paola Fioretto, Richard S. Fish, Adiel Fleischer, D Fleming-Brown, Lucy Fletcher, Roger E. Flora, C Foellinger, Nadia Edvige Foligno, Sylvain Forest, Z Forghani, K Forsyth, Deidre Fottrell-Gould, Patricia Fox, A. Frankel, Donald Fraser, Robert C. Frazier, K. Frederick, Natalie Freking, Helen French, Anne Froment, Bruno Fuchs, L Fuessl, Hideki Fujii, Akira Fujimoto, Akifumi Fujita, Ken‐ichi Fujita, Yasuko Fujita, Masafumi Fukagawa, Yusuke Fukao, Atsuko FUKASAWA, T Fuller, T Funayama, Erik Fung, Masashi Furukawa, Yusuke Furukawa, Masahide Furusho, Scott A. Gabel, J Gaidu, Sebastian Gaiser, Kathleen A. Gallo, Chris Galloway, Giovanni Gambaro, Chye Chung Gan, Chye Chung Gan, Ming Gao, K Garcia, M Garcia, Carlo Garofalo, Maureen J. Garrity, Amanda Garza, S Gasko, Mariana Gavrila, B Gebeyehu, A. Geddes, Giorgio Gentile, Arun George, Jyothis T. George, Loreto Gesualdo, Farid Ghalli, A Ghanem, Taneera Ghate, Sharang Ghavampour, Azmee Mohd Ghazi, Anca Gherman, U Giebeln-Hudnell, B. Gill, Sara Gillham, I Girakossyan, Matthias Girndt, Alfio Edoardo Giuffrida, Margaret Glenwright, T Glider, Rebecca Gloria, Deborah Glowski, BL Goh, CB Goh, Tomohito Gohda, Ronald Goldenberg, Rebecca F. Goldfaden, Charlie H. 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Harun, L Harvill, Arif Ul Hasan, Hiroki Hase, Fumi Hasegawa, Takeshi Hasegawa, Akiko Hashimoto, Chizuko Hashimoto, Manabu Hashimoto, S Hashimoto, S Haskett, SJ Hauske, Amret Hawfield, Tomohide Hayami, Matsuhiko Hayashi, Shinichiro Hayashi, Richard Haynes, Adil M. Hazara, Catherine Healy, J Hecktman, Gunnar H. Heine, Heather Henderson, R Henschel, Anita Hepditch, K. Herfurth, Guadalberto Hernández, A Hernandez Pena, Carlos Hernández-Cassis, WG Herrington, Charles A. Herzog, Sue Hewins, D Hewitt, L Hichkad, S Higashi, C Higuchi, Christopher Hill, Lisa Hill, Michael Hill, Tatsuhito Himeno, Alfred Hing, Yosuke Hirakawa, Ken‐ichi Hirata, Yushi Hirota, Tomoko Hisatake, S Hitchcock, Alexander J. Hodakowski, William Hodge, R. C. Hogan, U Hohenstatt, Bernd Hohenstein, Lai Seong Hooi, S Hope, Mark Hopley, Shunji HORIKAWA, Darya Hosein, Tetsuya Hosooka, Lifang Hou, Wanyin Hou, L Howie, A. G. Howson, Mary Ann Hozak, Zay Htet, X. Hu, Ying Hu, Jing Huang, Nazmul Huda, Lisa Hudig, Amy Hudson, Christian Hugo, Robert Hull, L. Hume, W Hundei, Nicholas Hunt, Alan Hunter, Sinéad Hurley, Alison Hurst, Cary T. Hutchinson, Takanori Hyo, FH Ibrahim, Sara T. Ibrahim, N Ihana, Takaya Ikeda, Atsushi Imai, Rui Imamine, Aya Inamori, H Inazawa, J Ingell, Kenta Inomata, Y. Inukai, M Ioka, A Irtiza-Ali, Tamara Isakova, W Isari, M Iselt, Atsushi Ishiguro, Kazuyuki Ishihara, Toru Ishikawa, Takuji Ishimoto, Kiyonobu Ishizuka, R Ismail, Satoshi Itano, Hisao Ito, Keiichi Ito, Masaki Ito, Yuzuru Ito, Shiho Iwagaitsu, Y Iwaita, Takashi Iwakura, Masahiro Iwamoto, Motoh Iwasa, Hitoshi Iwasaki, Shintaro Iwasaki, Kazuhiro Izumi, Kazuhiro Izumi, Takashi Izumi, SM Jaafar, Charlotte Jackson, Yves Jackson, G Jafari, Mahyar Jahangiriesmaili, Neemisha Jain, K. Jansson, Hiba Sabah Jasim, Lennox J. Jeffers, Alison Jenkins, M Jesky, Jorge Antonio Jesus Silva, D. Rohan Jeyarajah, Yue Jiang, Xue Jiao, Gustavo Jiménez, Bo-Yeong Jin, Qi Jin, J. Jochims, Beverly Johns, Carolyn J. Johnson, Thomas Johnson, Sagar Jolly, L Jones, L Jones, Sarah Jones, Tara L. Jones, Virginia Jones, Matthew Joseph, Shivam Joshi, P. G. Judge, NoorNabi Junejo, Salahuddin Junus, Martin Kächele, Takashi Kadowaki, Hirokazu Kadoya, Hideyoshi Kaga, Hirayasu Kai, Hiroshi Kajio, Wiebke Kaluza-Schilling, Lydia Kamaruzaman, A Kamarzarian, Yoshio Kamimura, Hajime Kamiya, Charlotte Kamundi, Toshiki Kan, Yasuhiko Kanaguchi, Akishige Kanazawa, Eiichiro Kanda, Shinji Kanegae, Kayo Kaneko, Kayo Kaneko, H-Y Kang, T Kano, Mahzuz Karim, Dennis G. Karounos, W Karsan, Rina Kasagi, Naoki Kashihara, Hiroki Katagiri, A Katanosaka, Akihiro Katayama, Michihito Katayama, Elliyyin Katiman, Katsuhito Kato, Masataka Kato, Noritoshi Kato, Sawako Kato, Tsuyoshi Kato, Yuzuru Kato, Yoshiaki Katsuda, Tomoyuki Katsuno, Jessica Kaufeld, Yasemin Kavak, Ikuko Kawai, Maki Kawai, Maki Kawai, Akiko Kawase, S Kawashima, Amir Kazory, Jessica Kearney, B Keith, Joanne Kellett, Scott D. Kelley, Michael H. Kershaw, Markus Ketteler, Q Khai, Quresh Khairullah, Hasnain Khandwala, KKL Khoo, Arif Khwaja, Kengo Kidokoro, Jan T. Kielstein, Masao Kihara, Charlotte H. Kimber, S Kimura, Haruyasu Kinashi, Hugh Kingston, Masaru Kinomura, E Kinsella-Perks, Masashi Kitagawa, Maiko Kitajima, Shinji Kitamura, Arihiro Kiyosue, Maki Kiyota, F Klauser, Gerhard Klausmann, W Kmietschak, Katherine M. Knapp, Cathryn Knight, A Knoppe, Carol Knott, Masaki Kobayashi, Rieko Kobayashi, Takaaki Kobayashi, Michael Koch, Satoru Kodama, Nobuyuki Kodani, Eisuke Kogure, Makoto Koizumi, H. Kojima, Takao Kojo, Nitin Kolhe, Hirotaka Komaba, Tatsuhiko Komiya, Hiroyuki Komori, SP Kon, Masahide Kondo, Masahide Kondo, Wen Kong, Masayo Konishi, Keiji Kono, Masayuki Koshino, Tomoki Kosugi, B Kothapalli, Tomasz Kozłowski, Bernhard Kraemer, Annette Kraemer-Guth, J Krappe, Daniel Kraus, Charalampos Kriatselis, Charles Krieger, Patel Krish, Burkhard Krüger, KR Ku Md Razi, Ying Kuan, Shuji Kubota, Simone Kühn, Praveen Kumar, Shinji Kume, Ingrid Kummer, R Kumuji, A. Küpper, Takumi Kuramae, L Kurian, C Kuribayashi, Rijo Kurien, Emi Kuroda, Takeshi Kurose, Ana P. Kutschat, Naoki Kuwabara, Hirofumi Kuwata, Gaetano La Manna, M.G. Lacey, K. J. Lafferty, Paula LaFleur, Vesta Lai, Emily Laity, A Lambert, Martin Landray, Michel R. Langlois, F. Latif, E Latore, E Laundy, D Laurienti, A Lawson, M Lay, I. Leal, I. Leal, AK Lee, J Lee, K. Lee, Raven Lee, S Lee, YY Lee, Young Hee Lee-Barkey, Niall Leonard, Giovanna Leoncini, CM Leong, Sarah Lerario, A Leslie, Adeera Levin, Andrew Lewington, J Li, Ni Li, X Li, Yanmin Li, Lawrence Liberti, ME Liberti, Adrian Liew, Y J Liew, U Lilavivat, Soo Kun Lim, YS Lim, E Limon, Ho Lin, Eirini Lioudaki, H Liu, Jie Liu, Lei Liu, Qingyun Liu, Wenjun Liu, Xiangqiong Liu, Zhizhao Liu, David Loader, H Lochhead, CL Loh, A. R. Lorimer, L. E. Loudermilk, Jerome Loutan, CK Low, CL Low, YM Low, Z Lozon, Yanqin Lu, Donata Lucci, Ute Ludwig, N Luker, Donald D. Lund, Robert A. Lustig, Stephen Lyle, Cameron Macdonald, Iain C. Macdougall, Rosario Machicado, Derek Maclean, Patrick MacLeod, A Madera, F. Madore, Kunimi Maeda, Hiroshi Maegawa, S Maeno, Marion Mafham, James S. Magee, Aldo P. Maggioni, DY Mah, Vahid Pirhajati Mahabadi, Masayuki Maiguma, Y Makita, Gail Makos, Licínio Manco, Roberto Mangiacapra, James L. Manley, P Mann, Satoshi Mano, G Marcotte, John M. Maris, Patrick B. Mark, Silke Markau, Miroslav Marković, Carol Marshall, María Martin, Charles Martinez, Socorro Piñones Martínez, Gustavo Celestino Martins, Ken Maruyama, Shoichi Maruyama, Kayleigh Marx, Agostino Maselli, Agnes Masengu, A Maskill, Shoichi Masumoto, Kosuke Masutani, Mayumi Matsumoto, T Matsunaga, N. Matsuoka, M. Matsushita, Michael Matthews, S. Matthias, Е. В. Матвиенко, Mathew Maurer, Patrick H. Maxwell, KJ Mayne, N Mazlan, SA Mazlan, A Mbuyisa, Kieran McCafferty, Frank McCarroll, Thomas McCarthy, C McClary-Wright, K McCray, Philip McDermott, Carrie R. McDonald, Renee McDougall, E McHaffie, K McIntosh, Todd O. McKinley, Stephen McLaughlin, Nathaniel McLean, Lynne McNeil, A Measor, James Meek, Anurag Mehta, Rupal Mehta, M. Melandri, Paolo Mené, Tian Meng, Jan Menne, K.A. Merritt, Sandra Merscher, C Meshykhi, Piergiorgio Messa, Laura Messinger, N. Miftari, Rachel K. Miller, Y E Miller, Eve Miller‐Hodges, Makiko Minatoguchi, M Miners, Roberto Minutolo, Tomohiro Mita, Y. Miura, Makoto Miyaji, Satoshi Miyamoto, Takeshi Miyatsuka, Megumi Miyazaki, Itsuko Miyazawa, Ryoji Mizumachi, Masashi Mizuno, Scott D. Moffat, FS Mohamad Nor, SN Mohamad Zaini, FA Mohamed Affandi, Cynthia Mohandas, Rozita Mohd, NA Mohd Fauzi, NH Mohd Sharif, Yusniza Yusoff, Louise Moist, A Moncada, Mahmoud Montasser, Andrew M. Moon, César A. Moran, Neal Morgan, James P. Moriarty, G Morig, Hiroshi Morinaga, Katsutaro Morino, T. Morisaki, Y Morishita, S Morlok, Alison Morris, F Morris, Sadek Mostafa, Y Mostefai, Mikio Motegi, N Motherwell, Davide Motta, Amy K. Mottl, R Moys, Sahar V. Mozaffari, James Muir, Jeffrey Mulhern, Stephen P. Mulligan, Yasuhisa Munakata, Christine Murakami, Masanori Murakoshi, Aleksandra Murawska, Kerry Murphy, Lee Murphy, Susan Murray, Hugh Murtagh, MA Musa, Lily Mushahar, Reem A. Mustafa, Ruslinda Mustafar, Manabu Muto, Evelyn Nadar, R Nagano, Toshihiko Nagasawa, Eiichi Nagashima, Hajime Nagasu, S Nagelberg, Harish Nair, Yusuke Nakagawa, M Nakahara, Jiro Nakamura, Ryô Nakamura, Tomonobu Nakamura, M Nakaoka, Eitaro Nakashima, Jun Nakata, M Nakata, Sakura Nakatani, Atsuko Nakatsuka, Yui Nakayama, Georges Nakhoul, Masaomi Nangaku, G Naverrete, A Navivala, I Nazeer, Lavinia Negrea, Chidambaram Nethaji, Erik T. Newman, SYA Ng, TJ Ng, L. Ngu, T Nimbkar, Hiroshi Nishi, Masahiro Nishi, Shinichi Nishi, Yoko Nishida, Akira Nishiyama, J. Niu, Ping Niu, Alessandro Nobili, Nozomi Nohara, Ikuko Nojima, John J. Nolan, H Nosseir, Masahiro Nozawa, Miles A. Nunn, S Nunokawa, M Oda, Makoto Oe, Yuki Oe, Kazumi Ogane, Wataru Ogawa, Toshio Ogihara, Godson Oguchi, Miho Ohsugi, Kazuhiro Oishi, Yosuke Okada, J Okajyo, Shinichiro Okamoto, K. Okamura, Olumide Olufuwa, Rotimi Oluyombo, Akiko Omata, Y Omori, LM Ong, Y.J. Ong, J Onyema, Amin Oomatia, Abraham Oommen, R. Oremus, Y Orimo, Vittorio Ortalda, Yukio Osaki, Yosuke Osawa, J Osmond Foster, Anthony O’Sullivan, Tomoyuki Otani, Noordin Othman, S. Otomo, John O’Toole, Lauren Owen, Tetsutaro Ozawa, Aparna Padiyar, Nicole Page, Sarah Pajak, Alexander Paliege, Ambarish Pandey, Ragini Pandey, H Pariani, J Park, M Parrigon, Jens Passauer, Margret Patecki, Mulchand S. Patel, Rishi Patel, Tulsi Patel, Zamurrud Patel, Rohan Paul, Rohan Paul, L. Paulsen, L Pavone, Amanda Soares Peixoto, J Peji, BC Peng, Kui Peng, Luigi Pennino, Eulália Pereira, Elena Perez, Pablo E. Pérgola, Francesco Pesce, Giuseppina Pessolano, William Petchey, EJ Petr, Thiemo Pfab, Paul J. Phelan, Richard Odame Phillips, Tiffany R. Phillips, Marion Phipps, G Piccinni, T Pickett, S. Pickworth, M. Piemontese, Daniel Pinto, Joyce M. Piper, J Plummer-Morgan, Diana Poehler, Lucio Polese, Valentina Vultaggio-Poma, Roberto Pontremoli, Anna Postal, C Pötz, Albert Power, Neeta Pradhan, Ravi Ranjan Pradhan, David Preiss, E Preiss, Kenzie L. Preston, Natalie Prib, Lori Lyn Price, Carlo Provenzano, C Pugay, Rafael Pulido, Franz Josef Putz, Y. Qiao, R. Quartagno, M Quashie-Akponeware, Ria Rabara, Rémi Rabasa‐Lhoret, Divya M. Radhakrishnan, Milford Radley, R Raff, S Raguwaran, Frederic F. Rahbari-Oskoui, Mahboob Rahman, Kartini Rahmat, S Ramadoss, S Ramanaidu, Sharmaine Ramasamy, Ramiza Ramza Ramli, S. Ramli, Tasha Ramsey, Alastair J. Rankin, Arash Rashidi, Laure Raymond, WAFA Razali, Kerry Read, H Reiner, A Reisler, Christina Reith, Jordan B. Renner, Bianka Rettenmaier, Leah Richmond, Dolores Rijos, Rodolfo Rivera, Vanessa Rivers, Hannah R. Robinson, Michael V. Rocco, I Rodriguez-Bachiller, R Rodriquez, Charles Roesch, Johannes Roesch, John Rogers, M Rohnstock, Steven B. Rolfsmeier, Mary J. Roman, A Romo, Alberto Rosati, Sarah Rosenberg, Talisa Ross, Xavier Rosselló, María Roura, Martine F. Roussel, Sergio Rovner, Subarna Roy, S Rucker, Lars Christian Rump, Maria Grazia Ruocco, Stacy A. Ruse, Francesco Paolo Russo, María Paula Russo, Mary Ryder, A Sabarai, Chiara Saccà, Richard Sachson, Emma Sadler, NS Safiee, Mandeep Sahani, A Saillant, J. Saini, Chie Saito, Shingo Saito, Kazushige Sakaguchi, Masahiro Sakai, Hotimah Masdan Salim, Chiara Salviani, Emily Sammons, Amanda K. Sampson, Fernand Samson, Peter Sandercock, S Sanguila, Gennaro Santorelli, Domenico Santoro, Nagaraju Sarabu, T Saram, Rebecca J. Sardell, Hiroyasu Sasajima, Takaya Sasaki, Scott G. Satko, Akemi Sato, Daisuke Sato, Hiroshi Sato, Hiroshi Sato, Jussara Leiko Sato, Tatsuyuki Sato, Yu Sato, Mamoru Satoh, Koji Sawada, Moritz Schanz, F Scheidemantel, Mara Schemmelmann, Elke Schettler, Volker Schettler, GR Schlieper, Caroline Schmidt, Gunnar Schmidt, U Schmidt, Hans-Jürgen Schmidt-Gürtler, Michelle Schmude, A Schneider, Ione Jayce Ceola Schneider, C Schneider-Danwitz, Michael Schömig, T. K. Schramm, A Schreiber, Severin Schricker, Bernd Schröppel, Lena Schulte‐Kemna, Eike C. Schulz, Björn Schumacher, Antonia Schuster, A. Schwab, Francesco Scolari, Andrew M. Scott, Werner Seeger, Werner Seeger, Mark S. Segal, Lena Seifert, Michael Seifert, Masatoshi Sekiya, R Sellars, MR Seman, Samir Shah, Samir Shah, L Shainberg, Mayooran Shanmuganathan, Fengmin Shao, Kumar Sharma, Claire C. Sharpe, M Sheikh-Ali, J Sheldon, Catriona Shenton, Amanda C. Shepherd, Martin Shepperd, Ray Sheridan, Zainab Sheriff, Yohei Shibata, Tetsuya Shigehara, Kenichi Shikata, Kohei Shimamura, Hitoshi Shimano, Yūji Shimizu, HIROMI SHIMODA, Koki Shin, G. V. Shivashankar, Nobuhiro Shojima, Rafael Filippelli-Silva, CSB Sim, Kathryn Simmons, Sanjay Sinha, Thomas Sitter, S. N. Sivanandam, Mette Tiedemann Skipper, Keren Sloan, Lindsey Sloan, Robin Smith, J. Smyth, Toluleyi Sobande, M Sobata, Subash Somalanka, Xicheng Song, Frank Sonntag, Brij Sood, SY Sor, Joseph Soufer, Holly D. Sparks, Giuseppe Spatoliatore, T Spinola, S. W. 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BACKGROUND: The EMPA-KIDNEY trial showed that empagliflozin reduced the risk of the primary composite outcome of kidney disease progression or cardiovascular death in patients with chronic kidney disease mainly through slowing progression. We aimed to assess how effects of empagliflozin might differ by primary kidney disease across its broad population. METHODS: , or death from kidney failure) were assessed using prespecified Cox models, and eGFR slope analyses used shared parameter models. Subgroup comparisons were performed by including relevant interaction terms in models. EMPA-KIDNEY is registered with ClinicalTrials.gov, NCT03594110. FINDINGS: per year (95% CI 1·16-1·59), representing a 50% (42-58) reduction in the rate of chronic eGFR decline. This relative effect of empagliflozin on chronic eGFR slope was similar in analyses by different primary kidney diseases, including in explorations by type of glomerular disease and diabetes (p values for heterogeneity all >0·1). INTERPRETATION: In a broad range of patients with chronic kidney disease at risk of progression, including a wide range of non-diabetic causes of chronic kidney disease, empagliflozin reduced risk of kidney disease progression. Relative effect sizes were broadly similar irrespective of the cause of primary kidney disease, suggesting that SGLT2 inhibitors should be part of a standard of care to minimise risk of kidney failure in chronic kidney disease. FUNDING: Boehringer Ingelheim, Eli Lilly, and UK Medical Research Council.