Antifungal Susceptibility and Mutations in the Squalene Epoxidase Gene in Dermatophytes of the Trichophyton mentagrophytes Species Complex

Authors: Xue Kong, Chao Tang, Ashutosh Singh, Sarah Ahmed, Abdullah M. S. Al‐Hatmi, Anuradha Chowdhary, Pietro Nenoff, Yvonne Gräser, Steven Hainsworth, Ping Zhan, Jacques F. Meis, Paul E. Verweij, Weida Liu, Sybren de Hoog - Antimicrobial Agents and Chemotherapy 2021 cited by 101

During the past decade, a prolonged and serious outbreak of dermatophytosis due to a terbinafine-resistant novel species in the Trichophyton mentagrophytes - T. interdigitale complex has been ongoing in India, and it has spread to several European countries. The objective of this study was to investigate the molecular background of the squalene epoxidase ( SQLE ) gene in order to understand the risk of emergence and spread of multiresistance in dermatophytes.