Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains

Authors: Christian Haenig, Nir Atias, Alexander K. Taylor, Arnon Mazza, Martin H. Schaefer, Jenny Russ, Sean‐Patrick Riechers, Shushant Jain, Maura Coughlin, Jean−Fred Fontaine, Brian D. Freibaum, Lydia Brusendorf, Martina Zenkner, Pablo Porras, Martin Stroedicke, Sigrid Schnoegl, Kristin Arnsburg, Annett Boeddrich, Lucia Pigazzini, Peter Heutink, J. Paul Taylor, Janine Kirstein, Miguel A. Andrade‐Navarro, Roded Sharan, Erich E. Wanker - Cell Reports 2020 cited by 119

that controls misfolding and aggregation of multiple ND-causing proteins in experimental model systems. Furthermore, it enables the prediction of ND-specific subnetworks and the identification of proteins, such as ATXN1 and MKL1, that are abnormally aggregated in postmortem brains of Alzheimer's disease patients, suggesting widespread protein aggregation in NDs.