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De novo glycan sequencing by electronic excitation dissociation MS 2 -guided MS 3 analysis on an Omnitrap-Orbitrap hybrid instrument

Authors: Juan Wei, Dimitris Papanastasiou, Mariangela Kosmopoulou, Athanasios Smyrnakis, Pengyu Hong, Nafisa Tursumamat, Joshua Klein, Chaoshuang Xia, Yang Tang, Joseph Zaia, Catherine E. Costello, Cheng Lin - Chemical Science 2023 cited by 18

EED MS 2 spectra were used to generate candidate topologies and guide selection of fragment(s) for MS 3 analysis. Isotoplogies indistinguishable at the MS 2 level may be differentiated by CID-EED MS 3 analysis.

De novo glycan sequencing by electronic excitation dissociation MS 2 -guided MS 3 analysis on an Omnitrap-Orbitrap hybrid instrument | Litlas