APOL1 Bi- and Monoallelic Variants and Chronic Kidney Disease in West Africans

Authors: Rasheed Gbadegesin, Ifeoma Ulasi, Samuel Ajayi, Yemi Raheem Raji, Timothy O. Olanrewaju, Charlotte Osafo, Adebowale Ademola, Adanze Onyenonachi Asinobi, Cheryl A. Winkler, David Burke, Fatiu A. Arogundade, Ivy Ekem, Jacob Plange‐Rhule, Manmak Mamven, Michael Mate-Kole, Olukemi K. Amodu, Richard Cooper, Sampson Antwi, Adebowale Adeyemo, Titilayo O. Ilori, Victoria Adabayeri, Alexander K. Nyarko, Anita Ghansah, Toyin Amira, Adaobi Solarin, Olugbenga Awobusuyi, Paul L. Kimmel, Frank C. Brosius, Muhammad Makusidi, Uzoma Odenigbo, Matthias Kretzler, Jeffrey B. Hodgin, Martin R. Pollak, Vincent Boima, B. I. Freedman, Nicholette D. Palmer, B. Collins, Milind A. Phadnis, Jill Smith, Celia I. Agwai, Ogochukwu Okoye, Aliyu Abdu, Jillian Wilson, Winfred W. Williams, Babatunde Lawal Salako, Rulan S. Parekh, Bamidele O. Tayo, Dwomoa Adu, Akinlolu Ojo - New England Journal of Medicine, NEJM 2024 cited by 74

BACKGROUND: variants with CKD in West Africans, a major group in the Black population. METHODS: risk alleles) by fitting logistic-regression models that controlled for covariates, including clinical site, age, and sex. RESULTS: variants with CKD or focal segmental glomerulosclerosis. CONCLUSIONS: variants were associated with 25% higher odds of CKD and 84% higher odds of focal segmental glomerulosclerosis. (Funded by the National Human Genome Research Institute and others.).