Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity

Authors: Hawley Kunz, Corey R. Hart, Kevin J. Gries, Mojtaba Parvizi, MARCELLO C. LAURENTI, Chiara Dalla Man, Natalie Moore, Xiaoyan Zhang, Zachary Ryan, Eric C. Polley, Michael D. Jensen, Adrian Vella, Ian R. Lanza - American Journal of Physiology-Endocrinology and Metabolism 2021 cited by 151

Adipose inflammation is proposed to be at the nexus of the systemic inflammation and metabolic derangements associated with obesity. The present study provides evidence to support adipose inflammation as a central feature of the pathophysiology of obesity. Adipose inflammation is associated with systemic and peripheral metabolic derangements, including increased systemic inflammation, reduced insulin sensitivity, and reduced skeletal muscle mitochondrial respiration.