Activity of Chitosan and Its Derivatives against Leishmania major and Leishmania mexicana In Vitro

Authors: Alaa Riezk, John G. Raynes, Vanessa Yardley, Sudaxshina Murdan, Simon L. Croft - Antimicrobial Agents and Chemotherapy 2019 cited by 35

There is an urgent need for safe, efficacious, affordable, and field-adapted drugs for the treatment of cutaneous leishmaniasis, which newly affects around 1.5 million people worldwide annually. Chitosan, a biodegradable cationic polysaccharide, has previously been reported to have antimicrobial, antileishmanial, and immunostimulatory activities.