Direct mechanocatalysis by resonant acoustic mixing (RAM)

Authors: Cameron B. Lennox, Tristan H. Borchers, Lori Gonnet, Christopher J. Barrett, Stefan G. Koenig, Karthik Nagapudi, Tomislav Friščić - Chemical Science 2023 cited by 67

a combination of benzyl azide formation and CuAAC reactions on a wide scope of reagents, provides control over reaction stoichiometry that is herein shown to be superior to that seen in solution or by using more conventional CuCl catalyst, and is applied for simple gram-scale synthesis of the anticonvulsant drug Rufinamide.