Magnetic Targeting of Nanotheranostics Enhances Cerenkov Radiation-Induced Photodynamic Therapy

Authors: Dalong Ni, Carolina A. Ferreira, Todd E. Barnhart, Virginia Quach, Bo Yu, Dawei Jiang, Weijun Wei, Huisheng Liu, Jonathan W. Engle, Ping Hu, Weibo Cai - Journal of the American Chemical Society 2018 cited by 192

Zr-MNP/TCPP exhibited high tumor accumulation under the presence of an external magnetic field, contributing to excellent tumor photodynamic therapeutic effect together with fluorescence, Cerenkov luminescence (CL), and Cerenkov resonance energy transfer (CRET) multimodal imaging to monitor the therapeutic process. The present study provides a major step forward in photodynamic therapy by developing an advanced phototherapy tool of magnetism-enhanced CR-induced PDT for effective targeting and treatment of tumors.