Surface Modified Ti3C2 MXene Nanosheets for Tumor Targeting Photothermal/Photodynamic/Chemo Synergistic Therapy
Ti 3 C 2 MXene is a new two-dimensional material exhibiting a variety of novel properties including good photothermal effect, and the capability of Ti 3 C 2 for multimodal tumor therapy is in urgent need of development. Herein, ultrathin Ti 3 C 2 MXene nanosheets (∼100 nm) have been synthesized by supplying additive Al 3+ to avoid Al loss and employed as a photothermal/photodynamic agent for cancer therapy. The as-obtained nanosheets exhibit outstanding mass extinction coefficient (28.6 Lg –1 cm –1 at 808 nm), superior photothermal conversion efficiency (∼58.3%), and effective singlet oxygen generation ( 1 O 2 ) upon 808 nm laser irradiation. Based on these Ti 3 C 2 nanosheets, a multifunctional nanoplatform (Ti 3 C 2 -DOX) is established via layer-by-layer surface modification with doxorubicin (DOX) and hyaluronic acid (HA). In vitro and in vivo experiments disclose that Ti 3 C 2 -DOX shows enhanced biocompatibility, tumor specific accumulation, and stimuli-responsive drug release behavior and achieve effective cancer cell killing and tumor tissue destruction through photothermal/photodynamic/chemo synergistic therapy.