Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis

Authors: Carlson Tsui, Núria Martínez, Mauro Gaya, Paula Maldonado, Miriam Llorian, Nathalie Legrave, Merja Rossi, James I. MacRae, Angus J.M. Cameron, Peter J. Parker, Michael Leitges, Andreas Bruckbauer, Facundo D. Batista - Immunity 2018 cited by 127

B cells exhibited defective antigen polarization and mTORC1 signaling. While altered antigen polarization impaired antigen presentation and likely restricted the potential of GC development, defective mTORC1 signaling impaired metabolic reprogramming, mitochondrial remodeling, and heme biosynthesis in these cells, which altogether overwhelmingly opposed plasma cell differentiation. Taken together, our study reveals mechanistic insights into the function of PKCβ as a key regulator of B cell polarity and metabolic reprogramming that instructs B cell fate.