Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats

Authors: Weilin Xu, Jun Yan, Umut Ocak, Cameron Lenahan, Anwen Shao, Jiping Tang, Jianmin Zhang, John H. Zhang - Theranostics 2020 cited by 161

The activation of MC1R with BMS-470539 significantly attenuated EBI after SAH by suppressing the oxidative stress, apoptosis, and mitochondrial fission through the AMPK/SIRT1/PGC-1α signaling pathway.