Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism

Authors: George S. Karagiannis, Jessica Pastoriza, Yarong Wang, Allison S. Harney, David Entenberg, Jeanine Pignatelli, Ved P. Sharma, Emily A. Xue, Esther Cheng, Timothy M. D’Alfonso, Joan G. Jones, Jesús Anampa, Thomas E. Rohan, Joseph A. Sparano, John S. Condeelis, Maja H. Oktay - Science Translational Medicine 2017 cited by 508

gene. Our results indicate that TMEM score increases and MENA isoform expression pattern changes with chemotherapy and can be used in predicting prometastatic changes in response to chemotherapy. Furthermore, inhibitors of TMEM function may improve clinical benefits of chemotherapy in the neoadjuvant setting or in metastatic disease.