Arginine Metabolism Powers Salmonella Resistance to Oxidative Stress

Authors: Alyssa Margolis, Lin Liu, Steffen Porwollik, James Karl A. Till, Weiping Chu, Michael McClelland, Andrés Vázquez‐Torres - Infection and Immunity 2023 cited by 32

Salmonella invades host cells and replicates inside acidified, remodeled vacuoles that are exposed to reactive oxygen species (ROS) generated by the innate immune response. Oxidative products of the phagocyte NADPH oxidase mediate antimicrobial activity, in part, by collapsing the ΔpH of intracellular Salmonella .