Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1

Authors: Sarah M. Davis, Vignesh Hariharan, Agnes S. Lo, Anton A. Turanov, Dimas Echeverria, Jacquelyn Sousa, Nicholas McHugh, Annabelle Biscans, Julia F. Alterman, S. Ananth Karumanchi, Melissa J. Moore, Anastasia Khvorova - Molecular Therapy — Nucleic Acids 2022 cited by 55

-targeting siRNAs. The optimization strategy here provides a framework for the chemical optimization of siRNAs for PE as well as other targets and clinical indications.