Histone H3K27 methyltransferase EZH2 regulates apoptotic and inflammatory responses in sepsis-induced AKI

Authors: Bojun Li, Yuqi Xia, Shuqin Mei, Zehua Ye, Baofeng Song, Xinzhou Yan, Fangyou Lin, Ting Rao, Weimin Yu, Changlin Mei, Jiayi Lv, Ming Wu, Zhiguo Mao, Xiangjun Zhou, Cheng Fan - Theranostics 2023 cited by 99

Our results indicate that silencing EZH2 can protect renal function by relieving transcriptional inhibition of Sox9, activating the Wnt/β-catenin pathway, and attenuating tubular epithelial apoptosis and inflammatory response of the renal interstitium. These results highlight the potential therapeutic value of targeting EZH2 in sepsis-induced AKI.