Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension

Authors: Natália R. Barbaro, Jason D. Foss, Dmytro O. Kryshtal, Nikita Tsyba, Shivani Kumaresan, Liang Xiao, Raymond L. Mernaugh, Hana A. Itani, Roxana Loperena, Wei Chen, Sergey Dikalov, Jens Titze, Björn C. Knollmann, David G. Harrison, Annet Kirabo - Cell Reports 2017 cited by 271

. The assembled NADPH oxidase produces superoxide with subsequent formation of immunogenic isolevuglandin (IsoLG)-protein adducts. DCs activated by excess sodium produce increased interleukin-1β (IL-1β) and promote T cell production of cytokines IL-17A and interferon gamma (IFN-γ). When adoptively transferred into naive mice, these DCs prime hypertension in response to a sub-pressor dose of angiotensin II. These findings provide a mechanistic link between salt, inflammation, and hypertension involving increased oxidative stress and IsoLG production in DCs.