Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection With accumulation of mutations in a patient with poorly controlled Human Immunodeficiency Virus infection

Authors: Tongai Maponga, Montenique Jeffries, Houriiyah Tegally, Andrew D. Sutherland, Eduan Wilkinson, Richard Lessells, Nokukhanya Msomi, Gert U. van Zyl, Túlio de Oliveira, Wolfgang Preiser - Clinical Infectious Diseases 2022 cited by 55

A 22-year-old woman with uncontrolled advanced human immunodeficiency virus (HIV) infection was persistently infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) beta variant for 9 months, the virus accumulating >20 additional mutations. Antiretroviral therapy suppressed HIV and cleared SARS-CoV-2 within 6 to 9 weeks. Increased vigilance is warranted to benefit affected individuals and prevent the emergence of novel SARS-CoV-2 variants.