Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging

Authors: Hui Zhang, Jiaming Li, Yang Yu, Jie Ren, Qiang Liu, Zhaoshi Bao, Shuhui Sun, Xiaoqian Liu, Shuai Ma, Zunpeng Liu, Kaowen Yan, Zeming Wu, Yanling Fan, Xiaoyan Sun, Yixin Zhang, Qianzhao Ji, Fang Cheng, Penghu Wei, Xibo Ma, Shiqiang Zhang, Zhengwei Xie, Yuyu Niu, Yan‐Jiang Wang, Jing‐Dong J. Han, Tao Jiang, Guoguang Zhao, Weizhi Ji, Juan Carlos Izpisúa Belmonte, Si Wang, Jing Qu, Weiqi Zhang, Guang‐Hui Liu - Cell Reports 2023 cited by 48

(Cell Reports 42, 112593; June 27, 2023) In the originally published version of this article, there was an inaccurately presented picture in Figure 5J (si-NC panel). Figure 5 has been corrected in the paper online and also appears below. This correction does not affect any results, conclusions, or discussions of this paper. The authors regret this error. Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal agingZhang et al.Cell ReportsMay 31, 2023In BriefZhang et al. establish a granular view of the molecular alterations underlying primate FL aging through multi-omics profiling, neuropathological examination, and in vitro modeling. It reveals that, during neuronal aging, nuclear lamina erosion induces the reactivation of ERVs and contributes to neuronal degeneration. Full-Text PDF Open Access