Gut bacterial dysbiosis and instability is associated with the onset of complications and mortality in COVID-19

Authors: David Schult, Sandra Reitmeier, Plamena Koyumdzhieva, Tobias Lahmer, Moritz Middelhoff, Johanna Erber, Jochen Schneider, Juliane Kager, М. А. Фролова, Julia Horstmann, Lisa Fricke, Katja Steiger, Moritz Jesinghaus, Klaus‐Peter Janssen, Ulrike Protzer, Klaus Neuhaus, Roland M. Schmid, Dirk Haller, Michael Quante - Gut Microbes 2022 cited by 91

ssp.). We demonstrated that a stable gut bacterial composition was associated with a favorable disease progression. Based on gut microbial profiles, we identified a model to estimate mortality in COVID-19. Gut microbiota are associated with the occurrence of complications in COVID-19 and may thereby influencing disease severity. A stable gut microbial composition may contribute to a favorable disease progression and using bacterial signatures to estimate mortality could contribute to diagnostic approaches. Importantly, we highlight challenges in the analysis of microbial data in the context of hospitalization.