Waning Vaccine Effectiveness Against Influenza-Associated Hospitalizations Among Adults, 2015–2016 to 2018–2019, United States Hospitalized Adult Influenza Vaccine Effectiveness Network

Authors: Jill M. Ferdinands, Manjusha Gaglani, Emily T. Martin, Arnold S. Monto, Donald B. Middleton, Fernanda P. Silveira, H. Keipp Talbot, Richard K. Zimmerman, Manish M. Patel - Clinical Infectious Diseases 2021 cited by 59

We observed decreased effectiveness of influenza vaccine with increasing time since vaccination for prevention of influenza A(H3N2), influenza A(H1N1)pdm09, and influenza B/Yamagata-associated hospitalizations among adults. Maximum vaccine effectiveness (VE) was observed shortly after vaccination, followed by an absolute decline in VE of about 8%-9% per month postvaccination.