Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Authors: Julien Barc, Rafik Tadros, Charlotte Glinge, David Y. Chiang, Mariam Jouni, Floriane Simonet, Sean J. Jurgens, Manon Baudic, Michele Nicastro, F Potet, Joost A. Offerhaus, Roddy Walsh, Seung Hoan Choi, Arie O. Verkerk, Yuka Mizusawa, Soraya Anys, Damien Minois, Marine Arnaud, Josselin Duchâteau, Yanushi D. Wijeyeratne, Alison Muir, Michael Papadakis, Silvia Castelletti, Margherita Torchio, Cristina Gil, Javier Lacunza, Daniela Giachino, Natascia Cerrato, Raphaël P. Martins, Óscar Campuzano, Sonia Van Dooren, Aurélie Thollet, Florence Kyndt, Andrea Mazzanti, Nicolas Clémenty, Arnaud Bisson, Anniek Corveleyn, Birgit Stallmeyer, Sven Dittmann, Johan Saenen, Antoine Noël, Shohreh Honarbakhsh, Boris Rudic, Halim Marzak, Matthew Rowe, Claire Federspiel, Sophie Le Page, Leslie Placide, Antoine Milhem, Héctor Barajas-Martínez, Britt Maria Beckmann, Ingrid P.C. Krapels, Johannes Steinfurt, Bo Gregers Winkel, Reza Jabbari, M. Benjamin Shoemaker, Bas J. Boukens, Doris Škorić‐Milosavljević, Hennie Bikker, Federico Manevy, Peter Lichtner, Marta Ribasés, Thomas Meitinger, Martina Müller‐Nurasyid, KORA-Study Group, Konstantin Strauch, Annette Peters, Holger Schulz, Lars Schwettmann, Reiner Leidl, Margit Heier, Jan H. Veldink, Leonard H. van den Berg, Philip Van Damme, Daniele Cusi, Chiara Lanzani, Sidwell Rigade, Éric Charpentier, Estelle Baron, Stéphanie Bonnaud, Simon Lecointe, Audrey Donnart, Hervé Le Marec, Stéphanie Chatel, Matilde Karakachoff, Stéphane Bezieau, Barry London, Jacob Tfelt‐Hansen, Dan M. Roden, Katja E. Odening, Marina Cerrone, Larry A. Chinitz, Paul G.A. Volders, Maarten P. van den Berg, Gabriel Laurent, Laurence Faivre, Charles Antzelevitch, Stefan Kääb, Alain Al Arnaout, Jean‐Marc Dupuis, Jean‐Luc Pasquié, Olivier Billon, Jason D. Roberts, Laurence Jesel, Martin Borggrefe, Pier D. Lambiase, Jacques Mansourati, Bart Loeys, Antoine Leenhardt, Pascale Guicheney, Philippe Maury, Eric Schulze‐Bahr, Tomas Robyns, Jeroen Breckpot, Dominique Babuty, Silvia G. Priori, Carlo Napolitano, Pascal Defaye, Frédéric Anselme, J P Darmon, François Wiart, Carlo de Asmundis, Pedro Brugada, Ramón Brugada, Elena Arbelo, Josép Brugada, Philippe Mabo, Nathalie Béhar, Carla Giustetto, María Sabater‐Molina, Juan R. Gimeno, Can Hasdemir, Peter J. Schwartz, Lia Crotti, Pascal McKeown, Sanjay Sharma, Elijah R. Behr, Michel Haı̈ssaguerre, Frédéric Sacher, Caroline Rooryck, Hanno L. Tan, Carol Ann Remme, Pieter G. Postema, Mario Delmar, Patrick T. Ellinor, Steven A. Lubitz, Jean‐Baptiste Gourraud, Michael W.T. Tanck, Alfred L. George, Calum A. MacRae, Paul W. Burridge, Christian Dina, Vincent Probst, Arthur A. Wilde, Jean‐Jacques Schott, Richard Redon, Connie R. Bezzina - Nature Genetics 2022 cited by 142

1.5 expression as a new underlying molecular mechanism. Taken together, these findings broaden our understanding of the genetic architecture of BrS and provide new insights into its molecular underpinnings.