Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma

Authors: Khun Visith Keu, Timothy H. Witney, Shahriar Yaghoubi, Jarrett Rosenberg, Anita Kurien, Rachel Magnusson, John Williams, Frezghi Habte, Jamie R. Wagner, Stephen J. Forman, Christine E. Brown, Martin Allen-Auerbach, Johannes Czernin, Winson W. Tang, Michael C. Jensen, Behnam Badie, Sanjiv S. Gambhir - Science Translational Medicine 2017 cited by 330

F]FHBG imaging was safe and enabled the longitudinal imaging of T cells stably transfected with a PET reporter gene in patients. Further optimization of this imaging approach for monitoring in vivo cell trafficking should greatly benefit various cell-based therapies for cancer.