Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

Authors: Mengqi Li, Chen‐Song Zhang, Yue Zong, Jin-Wei Feng, Teng Ma, Meiqin Hu, Zhi‐Zhong Lin, Xiaotong Li, Changchuan Xie, Yaying Wu, Dong Jiang, Ying Li, Cixiong Zhang, Xiao Tian, Wen Wang, Yanyan Yang, Jie Chen, Jiwen Cui, Yu-Qing Wu, Xin Chen, Qingfeng Liu, Jianfeng Wu, Shu‐Yong Lin, Zhiyun Ye, Ying Liu, Hai-long Piao, Li Yu, Zhuan Zhou, Xiao‐Song Xie, D. Grahame Hardie, Sheng‐Cai Lin - Cell Metabolism 2019 cited by 146

levels in aged muscles, rejuvenating the animals' running capacity. Our study elucidates that TRPVs relay the FBP-free status of aldolase to the reconfiguration of v-ATPase, leading to AMPK activation in low glucose.