Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis

Authors: Jiawei Wu, Zhonghong Wei, Peng Cheng, Cheng Qian, Fangming Xu, Yang Yu, Aiyun Wang, Wenxing Chen, Zhiguang Sun, Yin Lu - Theranostics 2020 cited by 386

We showed that rhein could modulate gut microbiota, which indirectly changed purine metabolism in the intestine and subsequently alleviated colitis. Our study has identified a new approach to the clinical treatment of colitis.