Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients

Authors: Thomas Condamine, George A. Dominguez, Je‐In Youn, Andrew V. Kossenkov, Sridevi Mony, Kevin Alicea-Torres, Evgenii N. Tcyganov, Ayumi Hashimoto, Yulia Nefedova, Cindy Lin, Simona Partlová, Alfred L. Garfall, Dan T. Vogl, Xiaowei Xu, Stella C. Knight, George Malietzis, Gui Han Lee, Evgeniy Eruslanov, Steven Μ. Albelda, Xianwei Wang, Jawahar L. Mehta, Meenakshi Bewtra, Anil K. Rustgi, Neil Hockstein, Robert Witt, Gregory A. Masters, Brian Nam, Denis A. Smirnov, Manuel A. Sepúlveda, Dmitry I. Gabrilovich - Science Immunology 2016 cited by 799

neutrophils had gene signature, potent immune suppressive activity, up-regulation of ER stress, and other biochemical characteristics of PMN-MDSC. Moreover, induction of ER stress in neutrophils from healthy donors up-regulated LOX-1 expression and converted these cells to suppressive PMN-MDSC. Thus, we identified a specific marker of human PMN-MDSC associated with ER stress and lipid metabolism, which provides new insight to the biology and potential therapeutic targeting of these cells.