Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling

Wei‐Chen Yen; Yi‐Hsuan Wu; Chih‐Ching Wu; Hsin‐Ru Lin; Arnold Stern; Shih‐Hsiang Chen; Jwu‐Ching Shu; Daniel T. Chiu

doi:10.1016/j.redox.2019.101363

Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling

Authors: Wei‐Chen Yen, Yi‐Hsuan Wu, Chih‐Ching Wu, Hsin‐Ru Lin, Arnold Stern, Shih‐Hsiang Chen, Jwu‐Ching Shu, Daniel T. Chiu - Redox Biology 2019 cited by 79

) enhanced inflammasome activation in G6PD-kd THP-1 cells. G6PD knockdown decreased Staphylococcus aureus and Escherichia coli clearance in G6PD-kd THP-1 cells and G6PD-deficient PBMCs following inflammasome activation. These findings support the notion that enhanced pathogen susceptibility in G6PD deficiency is, in part, due to an altered redox signaling, which adversely affects inflammasome activation and the bactericidal response.