Validation of the Addenbrooke's Cognitive Examination III in Frontotemporal Dementia and Alzheimer's Disease
<b><i>Background/Aims:</i></b> The aims of this study were to validate the newly developed version of the<b> </b>Addenbrooke's Cognitive Examination (ACE-III) against standardised neuropsychological tests and its predecessor (ACE-R) in early dementia. <b><i>Methods:</i></b> A total of 61 patients with dementia (frontotemporal dementia, FTD, n = 33, and Alzheimer's disease, AD, n = 28) and 25 controls were included in the study. <b><i>Results:</i></b> ACE-III<b> </b>cognitive domains correlated significantly with standardised neuropsychological tests used in the assessment of attention, language, verbal memory and visuospatial function. The ACE-III also compared very favourably with its predecessor, the ACE-R, with similar levels of sensitivity and specificity. <b><i>Conclusion:</i></b> The results of this study provide objective validation of the ACE-III as a screening tool for cognitive deficits in FTD and AD.