Neuronal DAF-16-to-intestinal DAF-16 communication underlies organismal lifespan extension in C. elegans

Masaharu Uno; Yuri Tani; Masanori Nono; Emiko Okabe; Saya Kishimoto; Chika Takahashi; Ryoji Abe; Takuya Kurihara; Eisuke Nishida

doi:10.1016/j.isci.2021.102706

Neuronal DAF-16-to-intestinal DAF-16 communication underlies organismal lifespan extension in C. elegans

Authors: Masaharu Uno, Yuri Tani, Masanori Nono, Emiko Okabe, Saya Kishimoto, Chika Takahashi, Ryoji Abe, Takuya Kurihara, Eisuke Nishida - iScience 2021 cited by 55

knockout in neurons and the intestine, respectively. In addition, the systemic regulation of intestinal DAF-16 required the IIS pathway in intestinal and neurons. Collectively, these results highlight the importance of the neuronal DAF-16-to-intestinal DAF-16 communication for organismal lifespan regulation.