Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment

Authors: I‐Ying Kuo, You-En Yang, Pei‐Shan Yang, Yu‐Jou Tsai, Hong‐Tai Tzeng, Hung‐Chi Cheng, Wan‐Ting Kuo, Wu‐Chou Su, Chih‐Peng Chang, Yi‐Ching Wang - Theranostics 2021 cited by 75

Rab37/IL-6 trafficking pathway links with IL-6/STAT3/PD-1 transcription regulation to foster an immunosuppressive TME and combined IL-6/CTLA-4 blockade therapy exerts potent anti-tumor efficacy.