A genomic mutational constraint map using variation in 76,156 human genomes

Authors: Siwei Chen, Laurent C. Francioli, Julia K. Goodrich, Ryan L. Collins, Masahiro Kanai, Qingbo S. Wang, Jessica Alföldi, Nicholas A. Watts, Christopher Vittal, Laura D. Gauthier, Timothy Poterba, Michael W. Wilson, Yekaterina Tarasova, William Phu, Riley Grant, Mary T. Yohannes, Zan Koenig, Yossi Farjoun, Eric Banks, Stacey Donnelly, Stacey Gabriel, Namrata Gupta, Steven Ferriera, Charlotte Tolonen, Sam Novod, Louis Bergelson, David Roazen, Valentín Ruano-Rubio, Miguel Covarrubias, Christopher Llanwarne, Nikelle Petrillo, Gordon Wade, Thibault Jeandet, Ruchi Munshi, Kathleen Tibbetts, María T. Abreu, Carlos A. Aguilar‐Salinas, Tariq Ahmad, Christine M. Albert, Diego Ardissino, Irina M. Armean, Elizabeth G. Atkinson, Gil Atzmon, John Barnard, Samantha Baxter, Laurent Beaugerie, Emelia J. Benjamin, David Benjamin, Michael Boehnke, Lori L. Bonnycastle, Erwin P. Böttinger, Donald W. Bowden, Matthew J. Bown, Harrison Brand, Steven R. Brant, Ted Brookings, Sam Bryant, Sarah E. Calvo, Hannia Campos, John C. Chambers, Juliana C.N. Chan, Katherine R. Chao, Sinéad B. Chapman, Daniel I. Chasman, Rex L. Chisholm, Judy H. Cho, Rajiv Chowdhury, Mina K. Chung, Wendy K. Chung, Kristian Cibulskis, Bruce M. Cohen, Kristen M. Connolly, Adolfo Correa, Beryl B. Cummings, Dana Dabelea, John Danesh, Dawood Darbar, Phil Darnowsky, Joshua C. Denny, Ravindranath Duggirala, Josée Dupuis, Patrick T. Ellinor, Roberto Elosúa, James Emery, Eleina England, Jeanette Erdmann, Tõnu Esko, Emily Evangelista, Diane Fatkin, José C. Florez, André Franke, Jack Fu, Martti Färkkilâ, Kiran Garimella, Jeff Gentry, Gad Getz, David C. Glahn, Benjamin Gläser, Stephen J. Glatt, David B. Goldstein, Clicerio González, Leif Groop, Sanna Gudmundsson, Andrea Haessly, Christopher A. Haiman, Ira M. Hall, Craig L. Hanis, Matthew Harms, Mikko Hiltunen, Matti Holi, Christina M. Hultman, Chaim Jalas, Mikko Kallela, Diane Kaplan, Jaakko Kaprio, Sekar Kathiresan, Eimear E. Kenny, Bong‐Jo Kim, Young Jin Kim, Daniel A. King, George Kirov, Jaspal S. Kooner, Seppo Koskinen, Harlan M. Krumholz, Subra Kugathasan, Soo Heon Kwak, Markku Laakso, Nicole J. Lake, Trevyn Langsford, Kristen M. Laricchia, Terho Lehtimäki, Monkol Lek, Emily Lipscomb, Ruth J. F. Loos, Wenhan Lu, Steven A. Lubitz, Teresa Tusie Luna, Ronald C.W., Gregory M. Marcus, Jaume Marrugat, Kari M. Mattila, Steven A. McCarroll, Mark I. McCarthy, Jacob L. McCauley, Dermot McGovern, Ruth McPherson, James B. Meigs, Olle Melander, Andres Metspalu, Deborah A. Meyers, Eric Vallabh Minikel, Braxton D. Mitchell, Vamsi K. Mootha, Aliya Naheed, Saman Nazarian, Peter M. Nilsson, Michael O‘Donovan, Yukinori Okada, Döst Öngür, Lorena Orozco, Michael J. Owen, Colin Palmer, Nicholette D. Palmer, Aarno Palotie, Kyong Soo Park, Carlos N. Pato, Ann E. Pulver, Dan Rader, Nazneen Rahman, Alex P. Reiner, Anne M. Remes, Dan Rhodes, Stephen S. Rich, John D. Rioux, Samuli Ripatti, Dan M. Roden, Jerome I. Rotter, Nareh Sahakian, Danish Saleheen, Veikko Salomaa, Andrea Saltzman, Nilesh J. Samani, Kaitlin E. Samocha, Alba Sanchis-Juan, Jeremiah M. Scharf, Molly Schleicher, Heribert Schunkert, Sebastian Schönherr, Eleanor G. Seaby, Svati H. Shah, Megan Shand, Ted Sharpe, M. Benjamin Shoemaker, Tai E. Shyong, Edwin K. Silverman, Moriel Singer‐Berk, Pamela Sklar, Jonathan T. Smith, J. G. Smith, Hilkka Soininen, Harry Sokol, Rachel G. Son, José Soto, Tim D. Spector, Christine Stevens, Nathan O. Stitziel, Patrick F. Sullivan, Jaana Suvisaari, E Shyong Tai, Kent D. Taylor, Yik Ying Teo, Ming T. Tsuang, Tiinamaija Tuomi, Dan Turner, Teresa Tusié‐Luna, Erkki Vartiainen, Marquis P. Vawter, Lily Wang, Arcturus Wang, James S. Ware, Hugh Watkins, Rinse K. Weersma, Ben Weisburd, Maija Wessman, Nicola Whiffin, James G. Wilson, Ramnik J. Xavier, Anne O’Donnell‐Luria, Matthew Solomonson, Cotton Seed, Alicia R. Martin, Michael E. Talkowski, Heidi L. Rehm, Mark J. Daly, Grace Tiao, Benjamin M. Neale, Daniel G. MacArthur, Konrad J. Karczewski - Nature 2023 cited by 1,411