Monodisperse polysarcosine-based highly-loaded antibody-drug conjugates

Authors: Warren Viricel, Guy Fournet, Sabine Beaumel, Emeline Perrial, Sébastien Papot, Charles Dumontet, Benoı̂t Joseph - Chemical Science 2019 cited by 93

A new antibody-drug conjugate (ADC) chemical drug-linker platform based on polysarcosine enables increased drug-loading, improved pharmacokinetics and exquisite in vivo potency.