Engineered probiotics biofilm enhances osseointegration via immunoregulation and anti-infection

Authors: Lei Tan, Jieni Fu, Fan Feng, Xiangmei Liu, Zhenduo Cui, Bo Li, Yong Han, Yufeng Zheng, Kwk Yeung, Zhaoyang Li, Shengli Zhu, Yanqin Liang, Xiaobo Feng, Xianbao Wang, Shuilin Wu - Science Advances 2020 cited by 154

biofilm stimulate macrophages to secrete abundant osteogenic cytokines such as oncostatin M and improve osseointegration of the Ti implant. Inactivated probiotics modification can be a promising strategy to endow implants with both excellent self-antibacterial activity and osteointegration ability.