Correlation of In Vitro Susceptibility Based on MICs and Squalene Epoxidase Mutations with Clinical Response to Terbinafine in Patients with Tinea Corporis/Cruris

Authors: Ananta Khurana, Aradhana Masih, Anuradha Chowdhary, Kabir Sardana, Sagar Borker, Aastha Gupta, R. K. Gautam, Pankaj Sharma, Dhruv Jain - Antimicrobial Agents and Chemotherapy 2018 cited by 132

= 0.009). Interestingly, 8 of the 9 patients in group 3 harbored isolates exhibiting elevated TRB MICs (8 to 32 µg/ml) and SQLE mutations. The odds of achieving cure with TRB MIC < 1 µg/ml strains were 2.5 times the odds of achieving cure with the strain exhibiting MIC ≥1 µg/ml.